IRiS: Construction of ARG networks at genomic scales | Zendy

Asif Javed | Zendy; Marc Pybus | Zendy; Marta Melé | Zendy; Filippo Utro | Zendy; Jaume Bertranpetit | Zendy; Francesc Calafell | Zendy; Laxmi Parida | Zendy

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IRiS: Construction of ARG networks at genomic scales

Author(s) -

Asif Javed,

Marc Pybus,

Marta Melé,

Filippo Utro,

Jaume Bertranpetit,

Francesc Calafell,

Laxmi Parida

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr423

Subject(s) - extant taxon , computer science , ibm , population , iris (biosensor) , graph , set (abstract data type) , haplotype , theoretical computer science , biology , genetics , programming language , artificial intelligence , allele , evolutionary biology , physics , optics , demography , sociology , gene , biometrics

Given a set of extant haplotypes IRiS first detects high confidence recombination events in their shared genealogy. Next using the local sequence topology defined by each detected event, it integrates these recombinations into an ancestral recombination graph. While the current system has been calibrated for human population data, it is easily extendible to other species as well.

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