Stage prediction of embryonic stem cell differentiation from genome-wide expression data | Zendy

Lan Žagar | Zendy; Francesca Mulas | Zendy; Silvia Garagna | Zendy; Maurizio Zuccotti | Zendy; Riccardo Bellazzi | Zendy; Blaž Zupan | Zendy

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Stage prediction of embryonic stem cell differentiation from genome-wide expression data

Author(s) -

Lan Žagar,

Francesca Mulas,

Silvia Garagna,

Maurizio Zuccotti,

Riccardo Bellazzi,

Blaž Zupan

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr422

Subject(s) - embryonic stem cell , genome , stem cell , computational biology , biology , cellular differentiation , stage (stratigraphy) , expression (computer science) , computer science , genetics , gene , paleontology , programming language

The developmental stage of a cell can be determined by cellular morphology or various other observable indicators. Such classical markers could be complemented with modern surrogates, like whole-genome transcription profiles, that can encode the state of the entire organism and provide increased quantitative resolution. Recent findings suggest that such profiles provide sufficient information to reliably predict the cell's developmental stage.

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