Inferring statin-induced gene regulatory relationships in primary human hepatocytes | Zendy

Adrian Schröder | Zendy; Johannes Wollnik | Zendy; Clemens Wrzodek | Zendy; Andreas Dräger | Zendy; Michael Bonin | Zendy; Oliver Burk | Zendy; Maria Thomas | Zendy; Wolfgang E. Thasler | Zendy; Ulrich M. Zanger | Zendy; Andreas Zell | Zendy

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Inferring statin-induced gene regulatory relationships in primary human hepatocytes

Author(s) -

Adrian Schröder,

Johannes Wollnik,

Clemens Wrzodek,

Andreas Dräger,

Michael Bonin,

Oliver Burk,

Maria Thomas,

Wolfgang E. Thasler,

Ulrich M. Zanger,

Andreas Zell

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr416

Subject(s) - atorvastatin , computational biology , statin , transcription factor , drug discovery , microarray analysis techniques , microarray , gene , gene expression , biology , hmg coa reductase , bioinformatics , drug , cyp3a4 , reductase , pharmacology , cytochrome p450 , genetics , enzyme , biochemistry

Statins are the most widely used cholesterol-lowering drugs. The primary target of statins is HMG-CoA reductase, a key enzyme in cholesterol synthesis. However, statins elicit pleitropic responses including beneficial as well as adverse effects in the liver or other organs. Today, the regulatory mechanisms that cause these pleiotropic effects are not sufficiently understood.

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