A detailed investigation of accessibilities around target sites of siRNAs and miRNAs | Zendy

Hisanori Kiryu | Zendy; Goro Terai | Zendy; Osamu Imamura | Zendy; Hiroyuki Yoneyama | Zendy; Kenji Suzuki | Zendy; Kiyoshi Asai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A detailed investigation of accessibilities around target sites of siRNAs and miRNAs

Author(s) -

Hisanori Kiryu,

Goro Terai,

Osamu Imamura,

Hiroyuki Yoneyama,

Kenji Suzuki,

Kiyoshi Asai

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr276

Subject(s) - small interfering rna , rna , computational biology , microrna , base pair , trans acting sirna , transcription (linguistics) , gene silencing , biology , genetics , gene , linguistics , philosophy

The importance of RNA sequence analysis has been increasing since the discovery of various types of non-coding RNAs transcribed in animal cells. Conventional RNA sequence analyses have mainly focused on structured regions, which are stabilized by the stacking energies acting on adjacent base pairs. On the other hand, recent findings regarding the mechanisms of small interfering RNAs (siRNAs) and transcription regulation by microRNAs (miRNAs) indicate the importance of analyzing accessible regions where no base pairs exist. So far, relatively few studies have investigated the nature of such regions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research