parmigene—a parallel R package for mutual information estimation and gene network reconstruction | Zendy

Gabriele Sales | Zendy; Chiara Romualdi | Zendy

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parmigene—a parallel R package for mutual information estimation and gene network reconstruction

Author(s) -

Gabriele Sales,

Chiara Romualdi

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr274

Subject(s) - mutual information , estimator , computer science , r package , data mining , software , gene regulatory network , software package , estimation , theoretical computer science , artificial intelligence , gene , computational science , mathematics , statistics , biology , biochemistry , gene expression , management , economics , programming language

Inferring large transcriptional networks using mutual information has been shown to be effective in several experimental setup. Unfortunately, this approach has two main drawbacks: (i) several mutual information estimators are prone to biases and (ii) available software still has large computational costs when processing thousand of genes.

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