Reconstruction of genealogical relationships with applications to Phase III of HapMap | Zendy

Sofia Kyriazopoulou-Panagiotopoulou | Zendy; Dorna Kashef Haghighi | Zendy; Sarah J. Aerni | Zendy; Andreas Sundquist | Zendy; Sivan Bercovici | Zendy; Serafim Batzoglou | Zendy

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Reconstruction of genealogical relationships with applications to Phase III of HapMap

Author(s) -

Sofia Kyriazopoulou-Panagiotopoulou,

Dorna Kashef Haghighi,

Sarah J. Aerni,

Andreas Sundquist,

Sivan Bercovici,

Serafim Batzoglou

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr243

Subject(s) - international hapmap project , computer science , phase (matter) , computational biology , biology , genetics , haplotype , chemistry , gene , genotype , organic chemistry

Accurate inference of genealogical relationships between pairs of individuals is paramount in association studies, forensics and evolutionary analyses of wildlife populations. Current methods for relationship inference consider only a small set of close relationships and have limited to no power to distinguish between relationships with the same number of meioses separating the individuals under consideration (e.g. aunt-niece versus niece-aunt or first cousins versus great aunt-niece).

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