Predicting site-specific human selective pressure using evolutionary signatures | Zendy

Javad Sadri | Zendy; Abdoulaye Baniré Diallo | Zendy; Mathieu Blanchette | Zendy

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Predicting site-specific human selective pressure using evolutionary signatures

Author(s) -

Javad Sadri,

Abdoulaye Baniré Diallo,

Mathieu Blanchette

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr241

Subject(s) - computer science , computational biology , artificial intelligence , biological system , biology

The identification of non-coding functional regions of the human genome remains one of the main challenges of genomics. By observing how a given region evolved over time, one can detect signs of negative or positive selection hinting that the region may be functional. With the quickly increasing number of vertebrate genomes to compare with our own, this type of approach is set to become extremely powerful, provided the right analytical tools are available.

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