Environment specific substitution tables improve membrane protein alignment | Zendy

Jamie Hill | Zendy; Sebastian Kelm | Zendy; Jiye Shi | Zendy; Charlotte M. Deane | Zendy

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Environment specific substitution tables improve membrane protein alignment

Author(s) -

Jamie Hill,

Sebastian Kelm,

Jiye Shi,

Charlotte M. Deane

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr230

Subject(s) - substitution (logic) , membrane protein , pairwise comparison , protein secondary structure , computational biology , threading (protein sequence) , biology , variation (astronomy) , membrane , protein structure , chemistry , computer science , biochemistry , artificial intelligence , physics , astrophysics , programming language

Membrane proteins are both abundant and important in cells, but the small number of solved structures restricts our understanding of them. Here we consider whether membrane proteins undergo different substitutions from their soluble counterparts and whether these can be used to improve membrane protein alignments, and therefore improve prediction of their structure.

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