Physical Module Networks: an integrative approach for reconstructing transcription regulation | Zendy

Noa Novershtern | Zendy; Aviv Regev | Zendy; Nir Friedman | Zendy

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Physical Module Networks: an integrative approach for reconstructing transcription regulation

Author(s) -

Noa Novershtern,

Aviv Regev,

Nir Friedman

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr222

Subject(s) - gene regulatory network , computational biology , regulation of gene expression , biology , computer science , graph , transcription (linguistics) , transcription factor , gene , systems biology , gene expression , theoretical computer science , distributed computing , genetics , linguistics , philosophy

Deciphering the complex mechanisms by which regulatory networks control gene expression remains a major challenge. While some studies infer regulation from dependencies between the expression levels of putative regulators and their targets, others focus on measured physical interactions.

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