Accurate estimation of heritability in genome wide studies using random effects models | Zendy

David E. Golan | Zendy; Saharon Rosset | Zendy

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Accurate estimation of heritability in genome wide studies using random effects models

Author(s) -

David E. Golan,

Saharon Rosset

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr219

Subject(s) - heritability , estimation , computer science , random effects model , statistics , computational biology , econometrics , biology , mathematics , genetics , medicine , engineering , meta analysis , systems engineering

Random effects models have recently been introduced as an approach for analyzing genome wide association studies (GWASs), which allows estimation of overall heritability of traits without explicitly identifying the genetic loci responsible. Using this approach, Yang et al. (2010) have demonstrated that the heritability of height is much higher than the ~10% associated with identified genetic factors. However, Yang et al. (2010) relied on a heuristic for performing estimation in this model.

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