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Sorting the nuclear proteome
Author(s) -
Denis C. Bauer,
Kai Willadsen,
Fabian A. Buske,
KimAnh Lê Cao,
Timothy L. Bailey,
Graham Dellaire,
Mikael Bodén
Publication year - 2011
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btr217
Subject(s) - proteome , computational biology , nuclear protein , biology , nuclear transport , sorting , compartment (ship) , transcription factor , computer science , cell nucleus , bioinformatics , gene , genetics , oceanography , geology , programming language
Quantitative experimental analyses of the nuclear interior reveal a morphologically structured yet dynamic mix of membraneless compartments. Major nuclear events depend on the functional integrity and timely assembly of these intra-nuclear compartments. Yet, unknown drivers of protein mobility ensure that they are in the right place at the time when they are needed.

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