Structure-based de novo prediction of zinc-binding sites in proteins of unknown function
Author(s) -
Wei Zhao,
Meng Xu,
Zhi Liang,
Bo Ding,
Liwen Niu,
Haiyan Liu,
Maikun Teng
Publication year - 2011
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btr133
Subject(s) - computational biology , function (biology) , zinc , binding site , computer science , biology , chemistry , biochemistry , genetics , organic chemistry
Zinc-binding proteins are the most abundant metallo-proteins in Protein Data Bank (PDB). Accurate prediction of zinc-binding sites in proteins of unknown function may provide important clues for the inference of protein function. As zinc binding is often associated with characteristic 3D arrangements of zinc ligand residues, its prediction may benefit from using not only the sequence information but also the structure information of proteins.
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