Agos—a universal web tool for GW Argonaute-binding domain prediction | Zendy

Andrzej Zieleziński | Zendy; Wojciech M. Karłowski | Zendy

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Agos—a universal web tool for GW Argonaute-binding domain prediction

Author(s) -

Andrzej Zieleziński,

Wojciech M. Karłowski

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr128

Subject(s) - argonaute , domain (mathematical analysis) , computer science , computational biology , world wide web , biology , genetics , rna interference , mathematics , rna , gene , mathematical analysis

AGO(Argonaute)-binding domains, composed of repeated motifs, in which only binary combinations of tryptophan and glycine are conserved, bind AGO proteins and are essential during RNAi-mediated gene silencing. The amino acid sequence of this domain is extremely divergent and therefore very difficult to detect. Commonly used bioinformatic tools fail to identify tryptophan-glycine and/or glycine-tryptophan motifs (WG/GW) domains and currently there is no publicly available software which can detect these weakly conserved, but functional AGO-binding segments.

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