aCGH.Spline—an R package for aCGH dye bias normalization | Zendy

Tomas Fitzgerald | Zendy; Lee Larcombe | Zendy; Solena Le Scouarnec | Zendy; Stephen Clayton | Zendy; Diana Rajan | Zendy; Nigel P. Carter | Zendy; Richard Redon | Zendy

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aCGH.Spline—an R package for aCGH dye bias normalization

Author(s) -

Tomas Fitzgerald,

Lee Larcombe,

Solena Le Scouarnec,

Stephen Clayton,

Diana Rajan,

Nigel P. Carter,

Richard Redon

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr107

Subject(s) - normalization (sociology) , r package , spline (mechanical) , computer science , computational biology , artificial intelligence , biology , genetics , physics , sociology , programming language , anthropology , thermodynamics

The careful normalization of array-based comparative genomic hybridization (aCGH) data is of critical importance for the accurate detection of copy number changes. The difference in labelling affinity between the two fluorophores used in aCGH-usually Cy5 and Cy3-can be observed as a bias within the intensity distributions. If left unchecked, this bias is likely to skew data interpretation during downstream analysis and lead to an increased number of false discoveries.

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