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R453Plus1Toolbox: an R/Bioconductor package for analyzing Roche 454 Sequencing data
Author(s) -
HansUlrich Klein,
Christoph Bartenhagen,
Alexander Kohlmann,
Vera Grossmann,
Christian Rückert,
Torsten Haferlach,
Martin Dugas
Publication year - 2011
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btr102
Subject(s) - bioconductor , computer science , r package , software , workflow , pipeline (software) , annotation , software package , data mining , computational biology , database , biology , programming language , genetics , artificial intelligence , gene
The R453Plus1Toolbox is an R/Bioconductor package for the analysis of 454 Sequencing data. Projects generated with Roche's data analysis software can be imported into R allowing advanced and customized analyses within the R/Bioconductor environment for sequencing data. Several methods were implemented extending the current functionality of Roche's software. These extensions include methods for quality assurance and annotation of detected variants. Further, a pipeline for the detection of structural variants, e.g. balanced chromosomal translocations, is provided.

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