Adjustment for local ancestry in genetic association analysis of admixed populations | Zendy

Xuexia Wang | Zendy; Xiaofeng Zhu | Zendy; Huaizhen Qin | Zendy; Stephen S. Rich | Zendy; Warren J. Ewens | Zendy; Chun Li | Zendy; Mingyao Li | Zendy

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Adjustment for local ancestry in genetic association analysis of admixed populations

Author(s) -

Xuexia Wang,

Xiaofeng Zhu,

Huaizhen Qin,

Stephen S. Rich,

Warren J. Ewens,

Chun Li,

Mingyao Li

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq709

Subject(s) - population stratification , spurious relationship , ancestry informative marker , single nucleotide polymorphism , genetic association , biology , population , association test , genetic genealogy , snp , locus (genetics) , logistic regression , allele frequency , type i and type ii errors , genetics , allele , statistics , genotype , demography , mathematics , sociology , gene

Admixed populations offer a unique opportunity for mapping diseases that have large disease allele frequency differences between ancestral populations. However, association analysis in such populations is challenging because population stratification may lead to association with loci unlinked to the disease locus.

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