Open source platform for the execution and analysis of mechanical refolding experiments | Zendy

Daniel Aioanei | Zendy; Marco Brucale | Zendy; Bruno Samorı̀ | Zendy

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Open source platform for the execution and analysis of mechanical refolding experiments

Author(s) -

Daniel Aioanei,

Marco Brucale,

Bruno Samorı̀

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq663

Subject(s) - software , kinetics , atomic force microscopy , folding (dsp implementation) , force spectroscopy , computer science , mit license , source code , protein folding , documentation , computational science , nanotechnology , biological system , chemistry , materials science , programming language , physics , mechanical engineering , engineering , biochemistry , quantum mechanics , biology

Single-molecule force spectroscopy has facilitated the experimental investigation of biomolecular force-coupled kinetics, from which the kinetics at zero force can be extrapolated via explicit theoretical models. The atomic force microscope (AFM) in particular is routinely used to study protein unfolding kinetics, but only rarely protein folding kinetics. The discrepancy arises because mechanical protein refolding studies are more technically challenging.

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