Evolutionary design principles and functional characteristics based on kingdom-specific network motifs | Zendy

Tae-Hwan Kim | Zendy; Junil Kim | Zendy; J. S. HeslopHarrison | Zendy; KwangHyun Cho | Zendy

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Evolutionary design principles and functional characteristics based on kingdom-specific network motifs

Author(s) -

Tae-Hwan Kim,

Junil Kim,

J. S. HeslopHarrison,

KwangHyun Cho

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq633

Subject(s) - multicellular organism , motif (music) , biology , computational biology , homo sapiens , biological network , robustness (evolution) , saccharomyces cerevisiae , complex network , computer science , evolutionary biology , genetics , gene , physics , world wide web , acoustics , sociology , anthropology

Network motifs within biological networks show non-random abundances in systems at different scales. Large directed protein networks at the cellular level are now well defined in several diverse species. We aimed to compare the nature of significantly observed two- and three-node network motifs across three different kingdoms (Arabidopsis thaliana for multicellular plants, Saccharomyces cerevisiae for unicellular fungi and Homo sapiens for animals).

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