iMAT: an integrative metabolic analysis tool
Author(s) -
Hadas Zur,
Eytan Ruppin,
Tomer Shlomi
Publication year - 2010
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btq602
Subject(s) - metabolic network , computational biology , computer science , metabolic pathway , flux (metallurgy) , metabolic flux analysis , flux balance analysis , metabolic activity , bioinformatics , enzyme , biology , metabolism , chemistry , biological system , biochemistry , organic chemistry
iMAT is an Integrative Metabolic Analysis Tool, enabling the integration of transcriptomic and proteomic data with genome-scale metabolic network models to predict enzymes' metabolic flux, based on the method previously described by Shlomi et al. The prediction of metabolic fluxes based on high-throughput molecular data sources could help to advance our understanding of cellular metabolism, since current experimental approaches are limited to measuring fluxes through merely a few dozen enzymes.
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