Preferential use of protein domain pairs as interaction mediators: order and transitivity | Zendy

Zohar BarnettItzhaki | Zendy; Eyal Akiva | Zendy; Hanah Margalit | Zendy

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Preferential use of protein domain pairs as interaction mediators: order and transitivity

Author(s) -

Zohar BarnettItzhaki,

Eyal Akiva,

Hanah Margalit

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq495

Subject(s) - transitive relation , domain (mathematical analysis) , context (archaeology) , protein–protein interaction , protein domain , function (biology) , interaction network , computer science , preference , biology , mathematics , genetics , combinatorics , gene , statistics , mathematical analysis , paleontology

Many protein-protein interactions (PPIs) are mediated by protein domains. The structural data of multi-domain PPIs reveal the domain pair (or pairs) that mediate a PPI, and implicitly also the domain pairs that are not involved in the interaction. By analyzing such data, preference relations between domain pairs as interaction mediators may be revealed.

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