A study of the efficiency of pooling in haplotype estimation | Zendy

Anthony Y. C. Kuk | Zendy; Jinfeng Xu | Zendy; Yaning Yang | Zendy

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A study of the efficiency of pooling in haplotype estimation

Author(s) -

Anthony Y. C. Kuk,

Jinfeng Xu,

Yaning Yang

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq492

Subject(s) - pooling , linkage disequilibrium , estimator , haplotype , efficiency , statistics , mathematics , computer science , econometrics , genetics , biology , allele , artificial intelligence , gene

It has been claimed in the literature that pooling DNA samples is efficient in estimating haplotype frequencies. There is, however, no theoretical justification based on calculation of statistical efficiency. In fact, the limited evidence given so far is based on simulation studies with small numbers of loci. With rapid advance in technology, it is of interest to see if pooling is still efficient when the number of loci increases.

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