ICPS: an integrative cancer profiler system | Zendy

Xinyu Zhang | Zendy; Lin Shi | Zendy; Yan Liu | Zendy; Feng Tian | Zendy; Haitao Zhao | Zendy; Xiaoping Miao | Zendy; Ming-lie Huang | Zendy; Xiaoyan Zhu | Zendy

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ICPS: an integrative cancer profiler system

Author(s) -

Xinyu Zhang,

Lin Shi,

Yan Liu,

Feng Tian,

Haitao Zhao,

Xiaoping Miao,

Ming-lie Huang,

Xiaoyan Zhu

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq487

Subject(s) - pipeline (software) , computational biology , computer science , carcinogenesis , cancer , bioinformatics , biology , genetics , programming language

Founded upon the database of 570 public signatures, ICPS is a web-based application to obtain biomarker profiles among 11 common cancers by integrating genomic alterations with transcription signatures on the basis of a previously developed integrative pipeline. ICPS supports both public data and user's in-house data, and performs meta-analysis at a cancer subtype level by combining heterogeneous datasets. Finally, ICPS returns the robust gene signature containing potential cancer biomarkers that may be useful to carcinogenesis study and clinical cancer diagnosis.

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