Computational analysis of tissue-specific gene networks: application to murine retinal functional studies | Zendy

Jianfei Hu | Zendy; Jun Wan | Zendy; László Hackler | Zendy; Donald J. Zack | Zendy; Jiang Qian | Zendy

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Computational analysis of tissue-specific gene networks: application to murine retinal functional studies

Author(s) -

Jianfei Hu,

Jun Wan,

László Hackler,

Donald J. Zack,

Jiang Qian

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq408

Subject(s) - gene , retina , gene ontology , computational biology , gene regulatory network , function (biology) , interaction network , variety (cybernetics) , biology , computer science , bayesian network , ontology , genetics , gene expression , artificial intelligence , neuroscience , philosophy , epistemology

The vertebrate retina is a complex neuronal tissue, and its development, normal functioning and response to injury and disease is subject to a variety of genetic factors. To understand better the regulatory and functional relationships between the genes expressed within the retina, we constructed an interactive gene network of the mouse retina by applying a Bayesian statistics approach to information derived from a variety of gene expression, protein-protein interaction and gene ontology annotation databases.

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