MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets | Zendy

Yitzhak Friedman | Zendy; Guy Naamati | Zendy; Michal Linial | Zendy

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MiRror: a combinatorial analysis web tool for ensembles of microRNAs and their targets

Author(s) -

Yitzhak Friedman,

Guy Naamati,

Michal Linial

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq298

Subject(s) - computer science , microrna , computational biology , artificial intelligence , biology , genetics , gene

The miRror application provides insights on microRNA (miRNA) regulation. It is based on the notion of a combinatorial regulation by an ensemble of miRNAs or genes. miRror integrates predictions from a dozen of miRNA resources that are based on complementary algorithms into a unified statistical framework. For miRNAs set as input, the online tool provides a ranked list of targets, based on set of resources selected by the user, according to their significance of being coordinately regulated. Symmetrically, a set of genes can be used as input to suggest a set of miRNAs. The user can restrict the analysis for the preferred tissue or cell line. miRror is suitable for analyzing results from miRNAs profiling, proteomics and gene expression arrays.

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