Streamlining the construction of large-scale dynamic models using generic kinetic equations | Zendy

Delali A. Adiamah | Zendy; Julia Handl | Zendy; JeanMarc Schwartz | Zendy

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Streamlining the construction of large-scale dynamic models using generic kinetic equations

Author(s) -

Delali A. Adiamah,

Julia Handl,

JeanMarc Schwartz

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq136

Subject(s) - dynamic equation , scale (ratio) , computer science , mathematics , kinetic energy , physics , classical mechanics , nonlinear system , quantum mechanics

Studying biological systems, not just at an individual component level but at a system-wide level, gives us great potential to understand fundamental functions and essential biological properties. Despite considerable advances in the topological analysis of metabolic networks, inadequate knowledge of the enzyme kinetic rate laws and their associated parameter values still hampers large-scale kinetic modelling. Furthermore, the integration of gene expression and protein levels into kinetic models is not straightforward.

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