Localized motif discovery in gene regulatory sequences
Author(s) -
Vipin Narang,
Ankush Mittal,
WingKin Sung
Publication year - 2010
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btq106
Subject(s) - motif (music) , computational biology , cis regulatory module , transcription factor , sequence motif , dna binding site , regulatory sequence , computer science , gene , structural motif , multiple sequence alignment , biology , genetics , sequence alignment , promoter , peptide sequence , gene expression , enhancer , physics , acoustics , biochemistry
Discovery of nucleotide motifs that are localized with respect to a certain biological landmark is important in several appli-cations, such as in regulatory sequences flanking the transcription start site, in the neighborhood of known transcription factor binding sites, and in transcription factor binding regions discovered by massively parallel sequencing (ChIP-Seq).
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