Genome-wide synteny through highly sensitive sequence alignment: Satsuma | Zendy

Manfred Grabherr | Zendy; Pamela J. Russell | Zendy; Miriah Meyer | Zendy; Evan Mauceli | Zendy; Jessica Alföldi | Zendy; Federica Di Palma | Zendy; Kerstin LindbladToh | Zendy

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Genome-wide synteny through highly sensitive sequence alignment: Satsuma

Author(s) -

Manfred Grabherr,

Pamela J. Russell,

Miriah Meyer,

Evan Mauceli,

Jessica Alföldi,

Federica Di Palma,

Kerstin LindbladToh

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq102

Subject(s) - synteny , genome , computer science , smith–waterman algorithm , software , genomics , comparative genomics , computational biology , mit license , biology , sequence alignment , genetics , operating system , gene , peptide sequence

Comparative genomics heavily relies on alignments of large and often complex DNA sequences. From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes).

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