How significant is a protein structure similarity with TM-score = 0.5? | Zendy

Jinrui Xu | Zendy; Yang Zhang | Zendy

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How significant is a protein structure similarity with TM-score = 0.5?

Author(s) -

Jinrui Xu,

Yang Zhang

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq066

Subject(s) - similarity (geometry) , f1 score , statistics , mathematics , quality score , structural similarity , test score , pattern recognition (psychology) , computer science , artificial intelligence , standardized test , image (mathematics) , metric (unit) , operations management , economics

Protein structure similarity is often measured by root mean squared deviation, global distance test score and template modeling score (TM-score). However, the scores themselves cannot provide information on how significant the structural similarity is. Also, it lacks a quantitative relation between the scores and conventional fold classifications. This article aims to answer two questions: (i) what is the statistical significance of TM-score? (ii) What is the probability of two proteins having the same fold given a specific TM-score?

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