FineStr: a web server for single-base-resolution nucleosome positioning | Zendy

Idan Gabdank | Zendy; Danny Barash | Zendy; Edward N. Trifonov | Zendy

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FineStr: a web server for single-base-resolution nucleosome positioning

Author(s) -

Idan Gabdank,

Danny Barash,

Edward N. Trifonov

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq030

Subject(s) - nucleosome , chromatin , computer science , web server , dna sequencing , dna , computational biology , base pair , sequence (biology) , biology , genetics , world wide web , the internet

The DNA in eukaryotic cells is packed into the chromatin that is composed of nucleosomes. Positioning of the nucleosome core particles on the sequence is a problem of great interest because of the role nucleosomes play in different cellular processes including gene regulation. Using the sequence structure of 10.4 base DNA repeat presented in our previous works and nucleosome core DNA sequences database, we have derived the complete nucleosome DNA bendability matrix of Caenorhabditis elegans. We have developed a web server named FineStr that allows users to upload genomic sequences in FASTA format and to perform a single-base-resolution nucleosome mapping on them.

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