rMAT - an R/Bioconductor package for analyzing ChIP-chip experiments | Zendy

Arnaud Droit | Zendy; Charles Cheung | Zendy; Raphaël Gottardo | Zendy

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rMAT - an R/Bioconductor package for analyzing ChIP-chip experiments

Author(s) -

Arnaud Droit,

Charles Cheung,

Raphaël Gottardo

Publication year - 2010

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btq023

Subject(s) - bioconductor , tiling array , chromatin immunoprecipitation , dna microarray , computer science , chip , mac os , r package , chip on chip , histone , computational biology , chromatin , chip sequencing , dna , biology , software , genetics , computational science , gene , operating system , nucleosome , gene expression , promoter , telecommunications

Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) has evolved as a popular technique to study DNA-protein binding or post-translational chromatin/histone modifications at the genomic level. However, the raw microarray intensities generate a massive amount of data, creating a need for efficient analysis algorithms and statistical methods to identify enriched regions.

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