Limited contribution of stem-loop potential to symmetry of single-stranded genomic DNA | Zendy

Shanghong Zhang | Zendy; Yazhi Huang | Zendy

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Limited contribution of stem-loop potential to symmetry of single-stranded genomic DNA

Author(s) -

Shanghong Zhang,

Yazhi Huang

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp703

Subject(s) - genome , biology , genetics , dna , oligonucleotide , computational biology , gene

The phenomenon of strand symmetry, which may provide clues to genome evolution, exists in all prokaryotic and eukaryotic genomes studied. Several possible mechanisms for its origins have been proposed, including: no strand biases for mutation and selection, strand inversion and selection of stem-loop structures. However, the relative contributions of these mechanisms to strand symmetry are not clear. In this article, we studied specifically the role of stem-loop potential of single-stranded DNA in strand symmetry.

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