Computing the shortest elementary flux modes in genome-scale metabolic networks | Zendy

Luís F. de Figueiredo | Zendy; Adam Podhorski | Zendy; Ángel Rubio | Zendy; Christoph Kaleta | Zendy; J. E. Beasley | Zendy; Stefan Schuster | Zendy; Francisco J. Planes | Zendy

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Computing the shortest elementary flux modes in genome-scale metabolic networks

Author(s) -

Luís F. de Figueiredo,

Adam Podhorski,

Ángel Rubio,

Christoph Kaleta,

J. E. Beasley,

Stefan Schuster,

Francisco J. Planes

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp564

Subject(s) - corynebacterium glutamicum , metabolic network , computer science , flux balance analysis , computation , flux (metallurgy) , mathematical optimization , computational biology , algorithm , biology , mathematics , chemistry , biochemistry , organic chemistry , gene

Elementary flux modes (EFMs) represent a key concept to analyze metabolic networks from a pathway-oriented perspective. In spite of considerable work in this field, the computation of the full set of elementary flux modes in large-scale metabolic networks still constitutes a challenging issue due to its underlying combinatorial complexity.

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