Copy number variation has little impact on bead-array-based measures of DNA methylation | Zendy

E. Andrés Houseman | Zendy; Brock C. Christensen | Zendy; Margaret R. Karagas | Zendy; Margaret Wrensch | Zendy; Heather H. Nelson | Zendy; Joseph L. Wiemels | Zendy; Shichun Zheng | Zendy; John K. Wiencke | Zendy; Karl T. Kelsey | Zendy; Carmen J. Marsit | Zendy

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Copy number variation has little impact on bead-array-based measures of DNA methylation

Author(s) -

E. Andrés Houseman,

Brock C. Christensen,

Margaret R. Karagas,

Margaret Wrensch,

Heather H. Nelson,

Joseph L. Wiemels,

Shichun Zheng,

John K. Wiencke,

Karl T. Kelsey,

Carmen J. Marsit

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp364

Subject(s) - dna methylation , methylation , copy number variation , biology , genetics , computational biology , head and neck squamous cell carcinoma , gene , cancer , genome , gene expression , head and neck cancer

Integration of various genome-scale measures of molecular alterations is of great interest to researchers aiming to better define disease processes or identify novel targets with clinical utility. Particularly important in cancer are measures of gene copy number DNA methylation. However, copy number variation may bias the measurement of DNA methylation. To investigate possible bias, we analyzed integrated data obtained from 19 head and neck squamous cell carcinoma (HNSCC) tumors and 23 mesothelioma tumors.

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