Hub genes with positive feedbacks function as master switches in developmental gene regulatory networks | Zendy

Chang Ho Seo | Zendy; JeongRae Kim | Zendy; Man-Sun Kim | Zendy; KwangHyun Cho | Zendy

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Hub genes with positive feedbacks function as master switches in developmental gene regulatory networks

Author(s) -

Chang Ho Seo,

JeongRae Kim,

Man-Sun Kim,

KwangHyun Cho

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp316

Subject(s) - gene regulatory network , function (biology) , master regulator , bistability , biology , positive feedback , computer science , cell fate determination , computational biology , gene , set (abstract data type) , neuroscience , genetics , gene expression , transcription factor , engineering , physics , quantum mechanics , electrical engineering , programming language

Spatio-temporal regulation of gene expression is an indispensable characteristic in the development processes of all animals. 'Master switches', a central set of regulatory genes whose states (on/off or activated/deactivated) determine specific developmental fate or cell-fate specification, play a pivotal role for whole developmental processes. In this study on genome-wide integrative network analysis the underlying design principles of developmental gene regulatory networks are examined.

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