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Sequence-to-structure alignment in template-based protein structure modeling for remote homologs remains a difficult problem even following the correct recognition of folds. Here we present MICAlign, a sequence-to-structure alignment tool that incorporates multiple sources of information from local structural contexts of template, sequence profiles, predicted secondary structures, solvent accessibilities, potential-like terms (including residue-residue contacts and solvent exposures) and pre-aligned structures and sequences. These features, together with a position-specific gap scheme, were integrated into conditional random fields through which the optimal parameters were automatically learned. MICAlign showed improved alignment accuracy over several other state-of-the-art alignment tools based on comparisons by using independent datasets.

MICAlign: a sequence-to-structure alignment tool integrating multiple sources of information in conditional random fields