Cross species analysis of microarray expression data
Author(s) -
Yong Lu,
Peter Huggins,
Ziv BarJoseph
Publication year - 2009
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btp247
Subject(s) - dna microarray , microarray analysis techniques , function (biology) , exponential growth , gene chip analysis , computational biology , expression (computer science) , computer science , data mining , sequence (biology) , microarray , biology , r package , contrast (vision) , gene , gene expression , genetics , artificial intelligence , mathematics , mathematical analysis , computational science , programming language
Many biological systems operate in a similar manner across a large number of species or conditions. Cross-species analysis of sequence and interaction data is often applied to determine the function of new genes. In contrast to these static measurements, microarrays measure the dynamic, condition-specific response of complex biological systems. The recent exponential growth in microarray expression datasets allows researchers to combine expression experiments from multiple species to identify genes that are not only conserved in sequence but also operated in a similar way in the different species studied.
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