Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy | Zendy

Nurcan Tunçbağ | Zendy; Attila Gürsoy | Zendy; Özlem Keskin | Zendy

Open Access

Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy

Author(s) -

Nurcan Tunçbağ,

Attila Gürsoy,

Özlem Keskin

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp240

Subject(s) - alanine scanning , hot spot (computer programming) , pairwise comparison , computer science , spots , support vector machine , discriminative model , biological system , chemistry , data mining , artificial intelligence , mutagenesis , mutation , biochemistry , biology , gene , operating system

Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy. These residues are critical in understanding the principles of protein interactions. Experimental studies like alanine scanning mutagenesis require significant effort; therefore, there is a need for computational methods to predict hot spots in protein interfaces.

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