A graphical algorithm for fast computation of identity coefficients and generalized kinship coefficients
Author(s) -
Mark Abney
Publication year - 2009
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btp185
Subject(s) - kinship , graph traversal , computer science , software , recursion (computer science) , tree traversal , graph , identity (music) , theoretical computer science , graphical model , algorithm , computation , artificial intelligence , programming language , political science , acoustics , law , physics
Computing the probability of identity by descent sharing among n genes given only the pedigree of those genes is a computationally challenging problem, if n or the pedigree size is large. Here, I present a novel graphical algorithm for efficiently computing all generalized kinship coefficients for n genes. The graphical description transforms the problem from doing many recursion on the pedigree to doing a single traversal of a structure referred to as the kinship graph.
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