A consistency-based consensus algorithm for de novo and reference-guided sequence assembly of short reads | Zendy

Tobias Rausch | Zendy; Sergey Koren | Zendy; Gennady Denisov | Zendy; David Weese | Zendy; AnneKatrin Emde | Zendy; Andreas GogolDöring | Zendy; Knut Reinert | Zendy

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A consistency-based consensus algorithm for de novo and reference-guided sequence assembly of short reads

Author(s) -

Tobias Rausch,

Sergey Koren,

Gennady Denisov,

David Weese,

AnneKatrin Emde,

Andreas GogolDöring,

Knut Reinert

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp131

Subject(s) - computer science , sequence assembly , consistency (knowledge bases) , documentation , reference genome , graph , data mining , insert (composites) , dna sequencing , programming language , theoretical computer science , artificial intelligence , biology , genetics , gene , gene expression , transcriptome , mechanical engineering , engineering

Novel high-throughput sequencing technologies pose new algorithmic challenges in handling massive amounts of short-read, high-coverage data. A robust and versatile consensus tool is of particular interest for such data since a sound multi-read alignment is a prerequisite for variation analyses, accurate genome assemblies and insert sequencing.

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