SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans | Zendy

Francesco Piva | Zendy; Matteo Giulietti | Zendy; Linda Nocchi | Zendy; Giovanni Principato | Zendy

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SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans

Author(s) -

Francesco Piva,

Matteo Giulietti,

Linda Nocchi,

Giovanni Principato

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp124

Subject(s) - rna splicing , rna , computational biology , rna binding protein , representation (politics) , computer science , database , biology , genetics , gene , politics , political science , law

The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.

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