Exploring phenotype-associated modules in an oral cavity tumor using an integrated framework
Author(s) -
Zhirong Sun,
Jie Luo,
Yun Zhou,
Junjie Luo,
Ke Liu,
Wenting Li
Publication year - 2009
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btp057
Subject(s) - computer science , node (physics) , perspective (graphical) , similarity (geometry) , phenotype , computational biology , feature (linguistics) , oral cavity , data mining , gene , theoretical computer science , biology , artificial intelligence , medicine , genetics , physics , linguistics , philosophy , image (mathematics) , quantum mechanics , orthodontics
Like most human diseases, tumors are complex traits, the genesis and development of which recruit a number of genes and several important biological processes. As proteins involved in common processes tend to be centralized in the same local area of protein-protein interaction networks, here a novel framework has been developed to identify which areas of the networks are most relevant to a phenotype.
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