BioCichlid: central dogma-based 3D visualization system of time-course microarray data on a hierarchical biological network | Zendy

Ryosuke Ishiwata | Zendy; M. Morioka | Zendy; Soichi Ogishima | Zendy; Hiroshi Tanaka | Zendy

Open Access

BioCichlid: central dogma-based 3D visualization system of time-course microarray data on a hierarchical biological network

Author(s) -

Ryosuke Ishiwata,

M. Morioka,

Soichi Ogishima,

Hiroshi Tanaka

Publication year - 2009

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btp008

Subject(s) - visualization , computer science , course (navigation) , microarray databases , computational biology , microarray analysis techniques , data visualization , data mining , biology , genetics , gene expression , engineering , gene , aerospace engineering

BioCichlid is a 3D visualization system of time-course microarray data on molecular networks, aiming at interpretation of gene expression data by transcriptional relationships based on the central dogma with physical and genetic interactions. BioCichlid visualizes both physical (protein) and genetic (regulatory) network layers, and provides animation of time-course gene expression data on the genetic network layer. Transcriptional regulations are represented to bridge the physical network (transcription factors) and genetic network (regulated genes) layers, thus integrating promoter analysis into the pathway mapping. BioCichlid enhances the interpretation of microarray data and allows for revealing the underlying mechanisms causing differential gene expressions.

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