Estimation of errors introduced by confocal imaging into the data on segmentation gene expression in Drosophila | Zendy

Ekaterina Myasnikova | Zendy; Svetlana Surkova | Zendy; Lena Panok | Zendy; Maria Samsonova | Zendy; John Reinitz | Zendy

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Estimation of errors introduced by confocal imaging into the data on segmentation gene expression in Drosophila

Author(s) -

Ekaterina Myasnikova,

Svetlana Surkova,

Lena Panok,

Maria Samsonova,

John Reinitz

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn620

Subject(s) - confocal , computer science , deconvolution , blastoderm , segmentation , microscope , computer vision , artificial intelligence , confocal microscopy , expression (computer science) , pattern recognition (psychology) , biology , gene , optics , algorithm , physics , genetics , programming language , embryogenesis

Currently the confocal scanning microscopy of fluorescently tagged molecules is extensively employed to acquire quantitative data on gene expression at cellular resolution. Following this approach, we generated a large dataset on the expression of segmentation genes in the Drosophila blastoderm, that is widely used in systems biology studies. As data accuracy is of critical importance for the success of studies in this field, we took a shot to evaluate possible errors introduced in the data by acquisition and processing methods. This article deals with errors introduced by confocal microscope.

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