SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap | Zendy

Andrew D. Johnson | Zendy; Robert E. Handsaker | Zendy; Sara L. Pulit | Zendy; Marcia M. Nizzari | Zendy; Christopher J. O’Donnell | Zendy; Paul I. W. de Bakker | Zendy

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SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

Author(s) -

Andrew D. Johnson,

Robert E. Handsaker,

Sara L. Pulit,

Marcia M. Nizzari,

Christopher J. O’Donnell,

Paul I. W. de Bakker

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn564

Subject(s) - international hapmap project , linkage disequilibrium , single nucleotide polymorphism , annotation , identification (biology) , computer science , computational biology , tag snp , genetic association , genome wide association study , biology , genetics , data mining , genotype , gene , botany

The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).

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