A better block partition and ligation strategy for individual haplotyping

Haplotype played an important role in the association studies of disease gene and drug responsivity over the past years, but the low throughput of expensive biological experiments largely limited its application. Alternatively, some efficient statistical methods were developed to deduce haplotypes from genotypes directly. Because these algorithms usually needed to estimate the frequencies of numerous possible haplotypes, the partition and ligation strategy was widely adopted to reduce the time complexity. The haplotypes were usually partitioned uniformly in the past, but recent studies showed that the haplotypes had their own block structure, which may be not uniform. More reasonable block partition and ligation strategy according to the haplotype structure may further improve the accuracy of individual haplotyping.