Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule | Zendy

Kristen A. Wieghaus | Zendy; Erwin P. Gianchandani | Zendy; Mikell Paige | Zendy; Milton L. Brown | Zendy; Edward A. Botchwey | Zendy; Jason A. Papin | Zendy

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Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecule

Author(s) -

Kristen A. Wieghaus,

Erwin P. Gianchandani,

Mikell Paige,

Milton L. Brown,

Edward A. Botchwey,

Jason A. Papin

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn451

Subject(s) - compendium , mechanism (biology) , computational biology , chemistry , computer science , biology , history , philosophy , archaeology , epistemology

Computational techniques have been applied to experimental datasets to identify drug mode-of-action. A shortcoming of existing approaches is the requirement of large reference databases of compound expression profiles. Here, we developed a new pathway-based compendium analysis that couples multi-timepoint, controlled microarray data for a single compound with systems-based network analysis to elucidate drug mechanism more efficiently.

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