Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation | Zendy

Viviane Galvão | Zendy; José García Vivas Miranda | Zendy; Ricardo RibeirodosSantos | Zendy

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Development of a two-dimensional agent-based model for chronic chagasic cardiomyopathy after stem cell transplantation

Author(s) -

Viviane Galvão,

José García Vivas Miranda,

Ricardo RibeirodosSantos

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn362

Subject(s) - stem cell , proinflammatory cytokine , bone marrow , transplantation , fibrosis , medicine , regeneration (biology) , cancer research , cytokine , tumor necrosis factor alpha , bone marrow stem cell , immunology , stem cell factor , pathology , haematopoiesis , biology , inflammation , microbiology and biotechnology

A significant issue in stem cell therapy is to understand the role of this type of cell in the tissue regeneration. To explain this mechanism, an experimental study has quantified that the bone marrow cell transplantation decreases the number of inflammatory cells and reduces the fibrosis area in chagasic mice. Using this experimental data, we have developed an agent-based computational model to investigate the regeneration of the chronic chagasic cardiomyopathy after bone marrow stem cell transplantation.

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