FlexStem: improving predictions of RNA secondary structures with pseudoknots by reducing the search space | Zendy

Xiang Chen | Zendy; SiMin He | Zendy; Dongbo Bu | Zendy; Fa Zhang | Zendy; Zhiyong Wang | Zendy; Runsheng Chen | Zendy; Wen Gao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

FlexStem: improving predictions of RNA secondary structures with pseudoknots by reducing the search space

Author(s) -

Xiang Chen,

SiMin He,

Dongbo Bu,

Fa Zhang,

Zhiyong Wang,

Runsheng Chen,

Wen Gao

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn327

Subject(s) - folding (dsp implementation) , nucleic acid secondary structure , rna , protein secondary structure , computer science , space (punctuation) , nucleic acid structure , software , algorithm , mathematics , physics , biology , engineering , genetics , nuclear magnetic resonance , gene , electrical engineering , programming language , operating system

RNA secondary structures with pseudoknots are often predicted by minimizing free energy, which is proved to be NP-hard. Due to kinetic reasons the real RNA secondary structure often has local instead of global minimum free energy. This implies that we may improve the performance of RNA secondary structure prediction by taking kinetics into account and minimize free energy in a local area.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research