Open AccessSystematic biological prioritization after a genome-wide association study: an application to nicotine dependence
Author(s) -
Scott F. Saccone,
Nancy L. Saccone,
Gary E. Swan,
Pamela A. F. Madden,
Alison Goate,
John P. Rice,
Laura J. Bierut
Publication year - 2008
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btn315
Subject(s) - genome wide association study , linkage disequilibrium , genetic association , single nucleotide polymorphism , computational biology , snp , biology , linkage (software) , snp genotyping , genetics , bioinformatics , genotype , gene
A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance.
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