Spidermonkey: rapid detection of co-evolving sites using Bayesian graphical models | Zendy

Art F. Y. Poon | Zendy; Fraser Lewis | Zendy; Simon D. W. Frost | Zendy; Sergei L. Kosakovsky Pond | Zendy

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Spidermonkey: rapid detection of co-evolving sites using Bayesian graphical models

Author(s) -

Art F. Y. Poon,

Fraser Lewis,

Simon D. W. Frost,

Sergei L. Kosakovsky Pond

Publication year - 2008

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btn313

Subject(s) - graphical model , co occurrence , computer science , bayesian probability , software , graphical user interface , data mining , artificial intelligence , programming language

Spidermonkey is a new component of the Datamonkey suite of phylogenetic tools that provides methods for detecting coevolving sites from a multiple alignment of homologous nucleotide or amino acid sequences. It reconstructs the substitution history of the alignment by maximum likelihood-based phylogenetic methods, and then analyzes the joint distribution of substitution events using Bayesian graphical models to identify significant associations among sites.

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